Lumpy skin disease (LSD) is an emerging transboundary viral disease of cattle originating from
the African continent. Here, we describe the first LSD outbreak reported in the Republic of Kazakhstan in July
2016, as well as associated clinical manifestations of the disease, diagnostic methods, and control measures taken to
combat further spread of the pathogen. Initially, LSD was reported in a cattle farm located 49 km from the Kazakh–
Russian border in Atyrau oblast in West Kazakhstan. Subsequently, the disease spread to neighbouring farms
situated within the same district. Following a preliminary investigation, the local State Veterinary Service declared
a strict quarantine according to the State Contingency Plan, along with immediate total stamping out and cattle
movement restrictions. During the outbreak, the number of affected cattle within an epidemiological unit reached
459 cattle out of 3557 registered susceptible cattle, with 12.90% morbidity and 0.96% mortality. This manuscript
presents the epidemiological situation; the diagnosis; the control measures, including mass vaccination; and the
stamping out campaign.